Abstract:

The aging process cannot be conceptualized by examining a single gene or a single pathway, but can best be addressed at the systems level. Aging is not only the sum total of shortened telomeres, denatured proteins and DNA molecules, or oxidative damage in the mitochondria. It attacks key regulatory nodes crucial for the stability of the biological network. Aging is the dynamic process of increasing imbalances in the organism as a result of degenerating biological processes. The old, the ill, and the injured all suffer from disarranged patterns of atoms. A single substitution of an A for a G in a DNA molecule can cause a significant change in the conductance of the molecule leading to cancer. Shanklin et al (2008) recently reported that a single substitution in the amino acid sequence of an enzyme changed its function into that of a theoretical distant ancestor. “It’s as if we turned back the clock nearly 2.5 billion years, to the time when oxygen first appeared in Earth’s atmosphere, to get a snapshot of how enzymes evolved to deal with reactive oxygen species,” said Shanklin, biochemist in the Brookhaven National Laboratory and the Karolinska Institute in Stockholm. Such research findings demonstrate how the sequence and interrelations of amino acids in a protein, or the sequence of base pairs in a DNA molecule can become determining factors between health and disease, aging and youth. Research has shown that gene expression is stronger when the gene is attached to the nuclear envelope (the membrane that surrounds the nucleus) than when the gene moves away from the nuclear envelope (Taddei et al, 2008). In other words, cells make use of the nuclear architecture or spatial organization of the nucleus to code epigenetic information. The DNA sequence alone doesn’t determine everything. The importance of nuclear architecture in regulating gene expression begs for scientific observation that goes beyond the study of atoms and molecules, i.e. the organism’s components. It is imperative that research focuses on the interrelations, sequence, orientation and spatial organization of an organism’s atoms and molecules, i.e. the dynamic processes that characterize the organism’s vital functions and survival. Electrical charge is a dynamic entity emerging from opposites such as protons and electrons attracting each other. How is electricity related to biological processes? Recent research has shown that DNA, proteins and cells, including stem cells, appear to be electrical in that they demonstrate conductivity or the presence of ionic currents (Li et al, 2008; Brown et al 2008). ATP synthesis, the primary source of cellular energy depends upon the driving source of electrons and protons. Given the required amount of electrons, free radicals (molecules with a missing electron) can be instantly stabilized. Many clinically used drugs such as calcium channel blockers and anesthetics interact specifically with ion channels. Many major pharmaceutical companies are showing increasing interest in ion channels as a new drug target. (Young et al, 2001). However, very little research has been invested in decoding endogenous electrical signals and the mathematical resultant of their overall activity. It is possible to electronically resonate the mathematical resultant of physiological energy as pioneer Pollock (1988-2008) has recently done in his lab by composing a pure analog multi-sine waveform that acts as a key to a lock with muscle neurons. Such pure analog waveform may act as a reparative force in itself, as well as an electronic diplomat to awaken the activation of biological reparative mechanisms involved in extended longevity. Read the rest of this entry »

Modern electronics and Molecular Biology research are combined to develop the specifications for a technology that promotes Healthy Anti-aging.  Resonating the firings, spatial organization and rhythms of electrically excitable cells leads to healing and rejuvenation in a completely safe, noninvasive method. The pervasive presence of ionic currents in core biological functions: (1) signal transduction, (2) the electrical conductivity of DNA, (3) the electromagnetic dynamics of protein conformation, render nanoelectricity the common denominator of all integral parts composing the Gestalt of a living organism.   However, to date, few devices pay attention to waveform formation that reflects the essence of cellular communications.  A simple square waveform is too impoverished to resonate the harmonious complexity of a biological system, the way a two piece band is insufficient in delivering the musical richness of a symphony.    The waveform is as important in cellular resonance as language is in verbal communication.  Language is confined by grammar and syntax rules in order to convey a message correctly.  Similarly, a waveform is confined by the spatial organization and rhythm of endogenous electrical signals that cells use in their multifaceted networking. Ion resonance has a harmonic  specificity that has to be encompassed before a device is designed.    There is a lot to be gained by developing a device that can emit signals capable of intertwining with those of signal transduction receptors (including G proteins, gene transcription and the activation of T cells).   Such a device will not only become the protagonist in Anti-aging but it will have sufficient sophistication to heal disease and enhance overall immune efficiency. 

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Aging is not just the sum total of individually deteriorating cells. Aging is the dynamic process of increasing imbalances in the systemic organization of these cells. Anti-aging reflects a multilevel approach that simultaneously targets a number of biological network modules. Identifying these dynamically organized network modules will be very important in formulating a model of how and why the aging process takes place and whether or not we can reverse aging by reorganizing an aged network model. How can a biological network be reorganized? The old, the ill, and the injured all suffer from disarranged patterns of atoms, whether disarranged by aging and accumulated free radicals, invading viruses, or unfortunate accidents. Aged and young are the Gestalts on opposite poles composed of variations in the arrangement of their dynamically organized networks.

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Gaining insight in the intricate mechanics of life and how to enhance and support it by utilizing certain nano current or micro current specifications will not only bring anti-aging research to a new level of awareness but will probably prelude the rise of “Proactive Medicine” where nano electricity is used to fine tune the body and keep while enhancing the immune system to combat and prevent disease.  The goal is to develop an “artificial language” via a sophisticated nanotechnology device that can communicate with the “language of life” as spoken at the cellular level.  This artificial language must be equivalent to a high definition signal, which implies that the specific device used must be capable of minimizing noise while utilizing compact clearly delineated, “high definition” waveforms and constant current.  This artificial intelligence device must be also capable of emitting nano amperes in very low frequencies in order to effectively resonate the nano electrical functioning of the cells.

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Recent advances in biochemistry, cell biology and genetics are giving us a concrete picture of the organism as an electrically intercommunicating whole that can be only fully captured by Quantum Coherence. Quantum Coherence reflects an entangled organic whole, where global and local are so thoroughly implicated as to be indistinguishable, and where each part is as much in control as it is sensitive and responsive. Imagine a very large jazz orchestra where everyone is doing his or her own thing while being perfectly in step and in tune with the whole. Viewed from the above macroscopic point of view, the biological system appears to be a biological Gestalt or a coherent organic whole interconnected by a multiplicity of electro-biochemical signals…

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